Data about the effects of all kinds of HCs on all test results are limited and sometimes inconclusive due to the large variety in HC, administration routes and dosages. Also, there were significant changes in levels of their bound molecules (testosterone, T3, T4, cortisol, vitamin D, IGF1 and GH). Although the majority of the effects were minor, a major increase was seen in angiotensinogen levels (90–375 %) and the concentrations of the binding proteins (SHBG, CBG, TBG, VDBP, and IGFBPs ). Most studies concerned the effects of combined oral contraceptives (COC) on the metabolic, hemostatic and (sex) steroids test results. Test parameters were differently affected by the dosage, duration, composition of HCs and route of administration. In this review, the effects of HCs on 91 routine chemistry tests, metabolic tests, and tests for liver function, hemostatic system, renal function, hormones, vitamins and minerals were evaluated. Hormonal contraceptives (HC) are widely used among women in reproductive ages. Liquid blood microsampling is expected to have similar advantages as dried blood microsampling and several studies suggest it to be a suitable approach to collect samples remotely for subsequent HbA 1c analysis in the lab. Lastly, the possibility of using liquid instead of dried blood microsamples is discussed. We focus on the used (dried) blood microsampling techniques, collection conditions, stability of the microsamples, sample extraction, analytical methods, method validation, correlation studies with conventional venous blood samples and patient satisfaction. This review provides a general and critical overview of these papers, along with specific points of attention that should be dealt with when aiming at implementing microsampling for reliable HbA 1c determination. However, the heterogeneity of the applied study designs and data evaluation is remarkable. Over the years, a substantial numbers of reports on HbA 1c and microsampling have been published. This is especially convenient/relevant for patients living in areas where venipuncture is impractical, or to support virtual consultations using telemedicine. Determination of the diabetes biomarker HbA 1c in self-collected microsamples to remotely monitor diabetes patients seems to be a very promising option which could eventually lead to better treatment adaptations and disease control. It is considered convenient and more patient-centric, enabling collection of the sample by the patient at her/his home with subsequent analysis in the lab following postal shipment. The collection of capillary blood microsamples via finger-prick has several advantages over traditional blood collection. Web of Science - Science Citation Index Expanded.Web of Science - Science Citation Index.Web of Science - Prous Science Integrity.Web of Science - Current Contents/Life Sciences.Ulrich's Periodicals Directory/ulrichsweb.Norwegian Register for Scientific Journals, Series and Publishers. KESLI-NDSL (Korean National Discovery for Science Leaders).Journal Citation Reports/Science Edition.Japan Science and Technology Agency (JST).CNKI Scholar (China National Knowledge Infrastructure).Chemical Abstracts Service (CAS) - SciFinder.Chemical Abstracts Service (CAS) - CAplus.Click on the section “International Journals” on the left-hand side where you find CCLM as the first listed journal.Ĭlinical Chemistry and Laboratory Medicine (CCLM) is covered by the following services: To take advantage of all the opportunities offered to members of the EFLM Academy, please access your personal area in the EFLM Academy at the link (if you do not remember your login details, you can use the option FORGOT PASSWORD). Research Articles, Reviews, Mini Reviews and Opinion Papers on all aspects of clinical chemistry and laboratory medicine, Guidelines and Recommendations, Point/Counterpoint Articles, Letters to the Editor, Editorials quality and safety in laboratory medicine.new reagents, instrumentation and technologies.disease-oriented topics (cardiovascular disease, cancer diagnostics, diabetes).clinical genomics and molecular biology.Letters to the Editor and Congress Abstracts are published online only. It is issued monthly, both in print and electronically. CCLM is led by a multi-institutional editorial board. All contributions submitted for publication in CCLM are single-blind peer reviewed by at least two experts in the field. CCLM is one of the leading journals in the field, with an impact factor over 8. It is focused on basic and applied research and cutting-edge clinical laboratory medicine. Clinical Chemistry and Laboratory Medicine ( CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine.
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